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    哈靈文獻:Science of The Total Environment

     Science of The Total Environment

    Volumes 622–623, 1 May 2018, Pages 214-221
     
    Developmental and metabolic responses of zebrafish (Danio rerio) embryos and 
     
    larvae to short-chain chlorinated paraffins (SCCPs) exposure
    Author links open overlay 
     
    panelXiaoqianRenabHaijunZhangaNingboGengaLiguoXingcYuZhaocFeidiWangabJipingChe
     
    na
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    https://doi.org/10.1016/j.scitotenv.2017.11.304Get rights and content
    Highlights
    Effects of SCCPs on development and metabolism of zebrafish were evaluated.
     
    SCCPs were highly toxic to zebrafish larvae, with 13-day LC50 value of 34.4 
     
    μg/L.
     
    Low-dose SCCPs slightly disturbed the overall metabolism in zebrafish embryos.
     
    SCCPs mainly disturbed metabolisms of glycerophospholipids, fatty acids and 
     
    purine.
     
     
    Abstract
    Short-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic 
     
    organisms, but their toxicity is yet not well characterized. In this study, 
     
    the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated, 
     
    and a metabolomics approach was adopted to explore the impact of SCCPs 
     
    exposure on the metabolism in zebrafish embryos. Exposure to SCCPs at 
     
    concentrations of 1–200 μg/L did not produce an observable effect on the 
     
    hatching rate and morphological deformities of zebrafish embryos/larvae. 
     
    However, the survival rate of zebrafish larvae in SCCPs exposure groups 
     
    decreased in a concentration-dependent manner. The 13-day 50% lethal 
     
    concentration (LC50) value of SCCPs was calculated to be 34.4 μg/L. Exposure 
     
    to SCCPs induced a significant change of overall metabolism, even at 
     
    environmentally relevant concentrations (1–5 μg/L). The most relevant 
     
    pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty 
     
    acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of 
     
    1–5 μg/L had begun to accelerate the β-oxidation of unsaturated fatty acids 
     
    and very long chain fatty acids, and affect the transformation of guanine to 
     
    xanthine in the pathway of purine metabolism. Furthermore, when the exposure 
     
    concentrations of SCCPs were increased to 50–200 μg/L, the levels of 
     
    phospholipids and amino acids were significantly raised; whereas the levels of 
     
    fatty acids, carnitines and inosine were significantly decreased. In view of 
     
    the significant effect on metabolism, the sub-chronic and chronic toxicity of 
     
    SCCPs to fish should be concerned.
     
    Graphical abstract
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    Keywords
    Short-chain chlorinated paraffinsZebrafish 
     
    embryo/larvaeMetabolomicsDevelopmental toxicity
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